...Severe Acne Nodulocystic acne and acne conglobated with many large, painful nodular or pustular lesions are present, along with many smaller papules, pustules, and comedones....»
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«...The Importance of Inhibiting the MicrocomedoEither topical or systemic retinoids can normalize keratinization within the follicle, and thus prevent the cohesion of follicular cells that leads to the formation of a microcomedo.Without intervention, the microcomedo may proceed either on a noninflammatory pathway to form mature comedones. Open comedones (blackheads) or closed comedones (whiteheads) - or on an inflammatory pathway to form papules, pustules, and nodules. ...»
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